Age-dependent phosphate homeostasis is regulated by a circulating factor.
نویسندگان
چکیده
To evaluate the age-dependent phosphate homeostasis, we studied the serum inorganic phosphate (P(i)) concentration in 78 recipients, aged 5-25 years, a year after renal transplantation (RT). The significant age-dependent decline of the serum P(i) concentration was observed in recipients (p < 0.0001) as well as in normal children. Our study revealed that a circulating factor may play a central role in the age-dependent change of phosphate regulation in human.
منابع مشابه
How fibroblast growth factor 23 works.
There is a discontinuum of hereditary and acquired disorders of phosphate homeostasis that are caused by either high or low circulating levels of the novel phosphaturic hormone fibroblastic growth factor 23 (FGF23). Disorders that are caused by high circulating levels of FGF23 are characterized by hypophosphatemia, decreased production of 1,25-dihydroxyvitamin D, and rickets/osteomalacia. On th...
متن کاملImproving Phosphorus Efficiency in Crops with Focus on Purple Acid Phosphatase: Potentials and Perspective
Low-phosphorus (P) stress as a key factor limiting plant growth and production is common in most agricultural soils. Most of the soil-applied phosphate will be rapidly immobilized and most of annually applied phosphate fertilizers are fixed in the soil in organic forms by adsorption, sedimentation and transformation. However, excess P application may lead to contamination of water sources by en...
متن کاملFGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
Fibroblast growth factor-23 (FGF23) is a bone-derived endocrine regulator of phosphate homeostasis which inhibits renal tubular phosphate reabsorption. Binding of circulating FGF23 to FGF receptors in the cell membrane requires the concurrent presence of the co-receptor αKlotho. It is still controversial whether αKlotho is expressed in the kidney proximal tubule, the principal site of phosphate...
متن کاملDefining the DNA Binding Site Recognized by the Fission Yeast Zn2Cys6 Transcription Factor Pho7 and Its Role in Phosphate Homeostasis
Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor Pho7, a member of the Zn2Cys6 family of fungal transcription regulators, is the central player in the starvation response. The DNA binding sites in the promoters of phosphate-responsive genes have not been defined, n...
متن کامل1 GCN 2 is required to increase fibroblast growth factor 21 and maintain hepatic 1 triglyceride homeostasis during asparaginase treatment
53 The anti-leukemic agent asparaginase triggers the amino acid response (AAR) in liver by 54 activating the eukaryotic initiation factor 2 (eIF2) kinase GCN2. To explore the 55 mechanism by which AAR induction is necessary to mitigate hepatic lipid accumulation 56 and prevent liver dysfunction during continued asparaginase treatment, wild-type and 57 Gcn2 null mice were injected once daily wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Nephron
دوره 92 4 شماره
صفحات -
تاریخ انتشار 2002